July 31, 2021
Abstract
Introduction
We evaluated whether insomnia symptom severity was associated with cognitive function, and whether this relationship was modified by biomarkers associated with Alzheimer’s disease risk.
Methods
We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status.
Results
More severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration. The association between insomnia symptoms and poorer memory recall was more pronounced in APOE ε4 allele carriers.
Discussion
Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE ε4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.
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Author: Andrée‐Ann Baril,
Alexa S. Beiser,
Erlan Sanchez,
Vincent Mysliwiec,
Susan Redline,
Daniel J. Gottlieb,
George T. O’Connor,
Mitzi M. Gonzales,
Dibya Himali,
Sudha Seshadri,
Jayandra J. Himali,
Matthew P. Pase
