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June 11, 2021

Representation of Mexican Americans in Alzheimer’s disease (AD) clinical research has been extremely poor.

Data were examined from the ongoing community-based, multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Participants underwent functional exams, clinical labs, neuropsychological testing, and 3T magnetic resonance imaging of the brain. Fasting proteomic markers were examined for predicting mild cognitive impairment (MCI) and AD using support vector machine models.

Data were examined from n = 1649 participants (Mexican American n = 866; non-Hispanic White n = 783). Proteomic profiles were highly accurate in detecting MCI (area under the curve [AUC] = 0.91) and dementia (AUC = 0.95). The proteomic profiles varied significantly between ethnic groups and disease state. Negative predictive value was excellent for ruling out MCI and dementia across ethnic groups.

A blood-based screening tool can serve as a method for increasing access to state-of-the-art AD clinical research by bridging between community-based and clinic-based settings.

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Author: Sid E. O’Bryant,
Fan Zhang,
Melissa Petersen,
James R. Hall,
Leigh A. Johnson,
Kristine Yaffe,
David Mason,
Meredith Braskie,
Robert A. Barber,
Robert A. Rissman,
Mark Mapstone,
Michelle M. Mielke,
Arthur W. Toga,
for the HABLE Study Team