September 9, 2021
Few longitudinal studies have explored the association between apolipoprotein E gene (APOE) status, sleep disturbances, and incident dementia among middle-aged participants.
Cox regression analyses explored the association of sleep duration, insomnia, and daytime napping with incident all-cause dementia and their interaction with APOE genetic risk among 397,777 middle-aged adults.
During a median of 10.8 years follow-up, sleeping more or fewer than 7 hours was associated with a higher dementia risk (hazard ratio [HR] for 5 vs 7 hours: 1.35, 95% confidence interval [CI] 1.11–1.64; HR for 9 vs 7 hours: 1.59; 95% CI 1.37–1.85) as was daytime napping (HR for often/all of the time vs never/rarely: 1.67; 95% CI 1.37–2.03). Stratified analyses revealed that the effects of sleep disturbances were similar across all APOE genetic risk groups.
Short and long sleep duration and daytime napping in middle-aged individuals are associated with the development of dementia in later life. Sleep duration and quality are important for everyone regardless of their genetic risk by APOE genotype.
Go to Source
Author: Eleni Palpatzis,